Dr. Darius Armstrong-James

Clinical senior Lecturer in Fungal Diseases

Research Focus

Macrophage immunobiology, aspergillosis, azole resistance

Scientific Activities

His Dr. Armstrong-James is a Clinical Senior Lecturer in Fungal Diseases based at Imperial College London. His primary interest is macrophage dysfunction in pulmonary immunity to Aspergillus fumigatus, where he has investigated the link between fungal germination, endosomal sensing, and cell death responses. His lab adopts a multidisciplinary approach spanning molecular immunology, single cell imagings, animal models and clinical studies. His research is supported by the MRC, Wellcome Trust, NIHR and NERC. He has also recently re-developed my interest in fungal phylogenetics and adaptation to the host.

Significant Publications

Shah A, Kannambath S, Herbst S, Rogers A, Soresi S, Carby M, Reed A, Mostowy S, Fisher MC, Shaunak S, Armstrong-James DPet al., 2016, Calcineurin Orchestrates Lateral Transfer of Aspergillus fumigatus during Macrophage Cell Death, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 194, Pages: 1127-1139, ISSN: 1073-449X

Abdolrasouli A, Rhodes J, Beale MA, Hagen F, Rogers TR, Chowdhary A, Meis JF, Armstrong-James D, Fisher MCet al., 2015, Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole-Genome Sequencing, MBIO, Vol: 6, ISSN: 2150-7511 Herbst S, Shah A, Moya MM, Marzola V, Jensen B, Reed A, Birrell MA, Saijo S, Mostowy S, Shaunak S, Armstrong-James Det al., 2015, Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus, EMBO MOLECULAR MEDICINE, Vol: 7, Pages: 240-258, ISSN: 1757-4676

Herbst S, Shah A, Moya MM, Marzola V, Jensen B, Reed A, Birrell MA, Saijo S, Mostowy S, Shaunak S, Armstrong-James Det al., 2015, Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus, EMBO MOLECULAR MEDICINE, Vol: 7, Pages: 240-258, ISSN: 1757-4676

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Collaborators