Prof. Alistair J P Brown
Assistant Professor Yeast and Fermentation
Research Focus
Pathogenomics of Candida albicans
Scientific Activities
(1) Environmental signalling and gene regulation in Candida albicans.
(2) Regulation of C. albicans virulence and fitness attributes during disease progression.
(3) Fungal genomics [transcript profiling, proteomics and bioinformatics].
(4) Fungal systems biology [mathematical modelling of nutrient and stress responses].
Significant Publications
Kaloriti, D., Jacobsen, M., Yin, Z., Patterson, M., Tillmann, A., Smith, D.A., Cook, E., You, T., Grimm, M.J., Bohovych, I., Grebogi, C., Segal, B.H., Gow, N.A.R., Haynes, K., Quinn, J. and Brown, A.J.P. (2014) Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. mBio 5, e01334-14.
Childers, D.S., Raziunaite, I., Mol Avelar, G., Potrykus, J., Budge, S., Stead, D., Gow, N.A.R, Lenardon, M., Ballou, E.R., MacCallum, D.M. and Brown, A.J.P. (2016) The rewiring of metabolic ubiquitination targets in a pathogenic yeast promotes metabolic flexibility, host colonization and virulence. PLoS Pathogens 12, e1005566.
Ballou, E.R., Avelar, G.M., Childers, D.S., Mackie, J., Bain, J.M., Wagener, J., Kastora, S.L., Panea, M.D., Hardison, S.E., Walker, L.A., Erwig, L.P., Munro, C.A., Gow, N.A.R., Brown, G.D., MacCallum, D.M. and Brown, A.J.P. (2016) Lactate signalling regulates fungal β-glucan masking and immune evasion. Nature Microbiology (in press).
Collaborators
Prof. Neil Gow FRS, FMedSci, FRSE, FRSB, FAAM
Deputy Vice-Chancellor for Research and Impact and Professor of Microbiology
More about Prof. Neil Gow...Prof. Carol Munro
Professor
More about Prof. Carol Munro...Dr. Alexandra Brand PhD, FRSB
Associate Professor & Wellcome Senior Research Fellow
More about Dr. Alexandra Brand...Prof. Gordon D. Brown
Professor
More about Prof. Gordon D. Brown...Dr. Donna MacCallum PhD FHEA FRSB
Senior Lecturer and Postgraduate Teaching Lead (School of Medicine, Medical Sciences & Nutrition)
More about Dr. Donna MacCallum...Prof. Janet Quinn
Professor of Eukaryotic Microbiology
More about Prof. Janet Quinn...
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Contact information
MRC Centre for Medical Mycology
University of Aberdeen
Aberdeen
AB25 2ZD
Email: Al.Brown@abdn.ac.uk
Phone: