Prof. Alistair J P Brown

Assistant Professor Yeast and Fermentation

Research Focus

Pathogenomics of Candida albicans

Scientific Activities

(1) Environmental signalling and gene regulation in Candida albicans.

(2) Regulation of C. albicans virulence and fitness attributes during disease progression.

(3) Fungal genomics [transcript profiling, proteomics and bioinformatics].

(4) Fungal systems biology [mathematical modelling of nutrient and stress responses].

Significant Publications

Kaloriti, D., Jacobsen, M., Yin, Z., Patterson, M., Tillmann, A., Smith, D.A., Cook, E., You, T., Grimm, M.J., Bohovych, I., Grebogi, C., Segal, B.H., Gow, N.A.R., Haynes, K., Quinn, J. and Brown, A.J.P. (2014) Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. mBio 5, e01334-14.

Childers, D.S., Raziunaite, I., Mol Avelar, G., Potrykus, J., Budge, S., Stead, D., Gow, N.A.R, Lenardon, M., Ballou, E.R., MacCallum, D.M. and Brown, A.J.P. (2016) The rewiring of metabolic ubiquitination targets in a pathogenic yeast promotes metabolic flexibility, host colonization and virulence. PLoS Pathogens 12, e1005566.

Ballou, E.R., Avelar, G.M., Childers, D.S., Mackie, J., Bain, J.M., Wagener, J., Kastora, S.L., Panea, M.D., Hardison, S.E., Walker, L.A., Erwig, L.P., Munro, C.A., Gow, N.A.R., Brown, G.D., MacCallum, D.M. and Brown, A.J.P. (2016) Lactate signalling regulates fungal β-glucan masking and immune evasion. Nature Microbiology (in press).

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Collaborators